2-Deoxy-D-glucose Powder

2-Deoxy-D-glucose powder Supplier

Inkampani i-Xi'an Yihui ingumkhiqizi ochwepheshe wempuphu ye-2-Deoxy-D-glucose engcono kakhulu . Singakhiqiza i-2DG enokuqukethwe okungu-99.9%. Ingasetshenziswa ekudleni, emithini, emikhiqizweni yezempilo, noma ezimonyweni futhi ihlangabezana nezindinganiso ze-USP, BP, EP, CP. Singakunikeza imikhiqizo yekhwalithi ephezulu ngamanani ancintisanayo kakhulu. Inketho yakho engcono kakhulu yomhlinzeki we-2DG ohlanzekile odumile yiNkampani i-Xi'an Yihui!

Iyini i-2-Deoxy-D-glucose powder?

2- Impuphu ye-glucose ye-Deoxy-D iyikhemikhali, ifomula yayo yamakhemikhali yi-C6H12O5 kanti isisindo sayo sama-molecule siyi-164.16 g/spook, i-CAS NO. yayo ingu- 154-17-6 . Ingushukela we-carbon ayisithupha ofana ne-glucose, kodwa ayinayo iqembu le-hydroxyl ku-snippet ehlukile ye-carbon, ngakho-ke ibizwa ngokuthi i-"deoxy" glucose. I-demitasse emhlophe enokuncibilika okuncane emanzini. I-2DG iyisiphazamisi se-metabolic esimtholampilo esingavimbela ukumuncwa nokusetshenziswa kwe-glucose yeseli, okuholela ekwehleni kwezimo ze-ATP ngaphakathi kwamaseli.

Lo muthi usebenza ikakhulukazi kumaseli wesimila kanye namagciwane athile athembele kushukela njengengxenye yawo eyinhloko ye-metabolic. Ukusebenzisa i-2DG kungabangela ngempumelelo la maseli ukuthi afe noma kwehlise izinga lokukhula kwawo. Ukwengeza, i-2DG isetshenziswa njengethuluzi ocwaningweni lwe-neuroscience kanye ne-metabolism ngoba ingalingisa isimo sokukhathala kwe-metabolic, iveze imininingwane yezindlela ze-metabolic metabolism.

Ukutholakala kwe-2-Deoxy-D-glucose kungalandelelwa emuva ekuqaleni kwawo-1950. Ngaleso sikhathi, ososayensi baseMelika u-Haskell Smith no-Morris Ficher bathola i-emulsion ebizwa ngokuthi i-2-deoxyglucose ngenkathi becwaninga izindlela zokuthatha i-cell glucose. Kamuva, omunye usosayensi u-Takashi Otsuka wathola ukuthi i-glucose engu-2-deoxy ingagxambukela kumetabolism ye-glucose yeseli futhi ivimbele ukuhlukana kwamaseli ngesikhathi sokuhlangana kwe-DNA.

Kamuva, ososayensi benze ucwaningo olwengeziwe nge- 2-DG powder futhi basungula ukuthi ingavimbela ukukhula kwamaseli athile kanye namagciwane ngenkathi inempahla encane kumaseli ajwayelekile.

Ukuze kuthuthukiswe ukusebenza kahle kwe-2DG, ososayensi baqala ukuklama nokuhlanganisa ama-mote afanayo. Kule nqubo, basungula ukuthi i-2DG iyisiphazamisi se-metabolic esisebenza kahle kakhulu, esikwazi ukuvimbela ngempumelelo ukumuncwa nokusetshenziswa kwe-glucose yeseli. Njengamanje, i-2DG isibe ithuluzi elibalulekile lokuhlola kanye nomuthi wezokwelapha.

Ulwazi Basic

Quality ejwayelekile

Inqubo Yokuhlanganisa

Inqubo yokwenziwa kwe -2-deoxy-D-glucose powder ihilela izinyathelo ezimbili:

Esinyathelweni sokuqala, i-glucose ingaphansi kwe-Knoevenagel condensation ngokusabela nge-methyl vinyl ketone ukuze ikhiqize inhlanganisela ye-α,β-unsaturated carbonyl.

Esinyathelweni sesibili, i-tInhlanganisela engagcwalisiwe yehliselwa emkhiqizweni oqondiwe ongu-2-deoxy-D-glucose ngokunciphisa i-hydrogenation.

Nazi izinqubo zokusabela ezithile:

Isinyathelo sokuqala sokuphendula isibalo:

IGlucose + Methyl vinyl ketone → α,β-unsaturated carbonyl compound

Indlela yokusabela yesinyathelo sokuqala:

Ngaphansi kwezimo ze-alkaline, i-glucose ne-methyl vinyl ketone isebenza njengama-nucleophilic reagents futhi idlula i-Knoevenagel condensation ngosizo lwe-thioacetone noma i-sodium hydroxide, ikhiqiza i-α, i-β-unsaturated carbonyl compound.

Isinyathelo sesibili sokusabela equation:

α,β-unsaturated carbonyl compound + Hydrogen gas + Catalyst → 2-deoxy-D-glucose

Indlela yokusabela yesinyathelo sesibili:

Lapho kukhona igesi ye-hydrogen kanye ne-catalyst, i-unsaturated carbonyl emulsion i-hydrogenated ukuze ikhiqize i-2-deoxy-D-glucose. I-essence catalyst efana neplatinamu noma ukuqaphela ngokuvamile isetshenziselwa le mpendulo ye-hydrogenation.

Kufanele kuqashelwe ukuthi kumane kuyisitayela esisodwa esivamile sokuhlanganiswa kweglucose engu-2-deoxy-D. Eqinisweni, kunezinye izindlela ezihlukene zokwenziwa, ezifana nokubuyekezwa kwamakhemikhali kwe-uracil kanye ne-microbial metabolism.

iyinhlanganisela ebaluleke kakhulu esetshenziswa kakhulu kwezokwelapha, i-biotechnology, kanye nemboni yokudla. Nazi ezinye izinzuzo zayo:

Ayinayo imiphumela emibi enobuthi emzimbeni womuntu futhi inomphumela wokubulala okhethiwe kumangqamuzana omdlavuza;

Ine-anti-virus, i-antifungal, i-anti-diabetes, i-anti-obesity kanye neminye imiphumela;

Ingamuncwa futhi isetshenziswe umzimba womuntu;

Ingasetshenziswa njenge-reagent ene-radiolabeled noma i-ejenti yokulungisa i-DNA ku-biotechnology;

Ingasetshenziswa njenge-sweetener enekhalori ephansi embonini yokudla;

Ngamafuphi, iyinhlanganisela ewusizo kakhulu enezinhlelo zokusebenza ezihlukahlukene.

Uyini Umsebenzi We-2 Deoxy Glucose?

I-2 deoxy glucose(2DG) iyi-analogue ye-glucose engenalo iqembu le-hydroxyl endaweni engu-2 yeringi ye-glucose. Ngokuvamile isetshenziswa ekuhloleni kwesayensi njengethuluzi lokuhlola i-glucose metabolism nezindlela ezihambisana nayo. Nansi eminye imisebenzi yayo:

1. Impahla ye-glycolysis 2DG ithathwa amaseli ngokusebenzisa izithuthi zikashukela futhi i-phosphorylated nge-hexokinase iye ku-2DG-6-phosphate, engakwazi ukuguqulwa kwe-glycolysis. ngakho-ke, i-2DG ingavimbela ngokuncintisana ukutholwa kwe-glucose kanye ne-glycolysis, okuyisinyathelo sokuqala kumetabolism yamandla.

2. I-Debaser ye-autophagy Autophagy iyindlela yokunciphisa amaselula esiza ukugcina i-homeostasis yeselula ngokuthola amaprotheni nama-organelles alimele noma angafuneki. I-2DG idala i-autophagy ngokuvimbela umgomo we-mammalian we-rapamycin(mTOR), okuholela ekusebenzeni kwezakhi zofuzo ezihlobene ne-autophagy.

3. I-Radiosensitizer: Amangqamuzana omdlavuza athatha i-glucose ephezulu kanye ne-glycolytic flux kunamaseli avamile, aziwa ngokuthi umphumela we-Warburg. Ngakho-ke, i-2DG ingakwazi ukukhetha ngokukhetha amangqamuzana omdlavuza ku-radiotherapy ngokuvimbela i-glycolysis kanye nokuthuthukisa izimpendulo zokucindezeleka kwamaselula.

4. Isehlo sokulungisa izimo ze-neurodegenerative I-2DG ikhonjiswe ukuthi ithuthukisa ukusebenza kwengqondo futhi yehlise i-neuropathology kumamodeli ezilwane zesikhalazo se-Alzheimer kanye nesikhalazo sika-Parkinson. Lokhu kungase kuthinte kusukela ekuthuthukisweni kwe-glucose metabolism ebuchosheni, kunciphise ukuvuvukala kwe-neuronal kanye nengcindezi ye-oxidative.

5. Ithuluzi lokubhala ilebula le-metabolic Ngenxa yesakhiwo sayo esifana ne-glucose kanye nekhono layo lokuhlanganisa ne-glycolysis, i-2-deoxy-d-glucose API ingasetshenziswa njengophawu lwe-metabolic ukutadisha isiphetho se-metabolic sama-motes akhishwe yi-glucose kumaseli nama-apkins.

Ngokufigqiwe,I-2-deoxy d glucose inemisebenzi eminingi ebalulekile ocwaningweni lwesayensi, okuhlanganisa njenge-inhibitor ye-glycolysis, i-inducer of autophagy, i-radiosensitizer, amandla okwelapha ezifo ze-neurodegenerative, kanye nethuluzi lokulebula kwe-metabolic. Ukusetshenziswa kwayo kunemithelela engaba khona kukho kokubili isayensi eyisisekelo kanye nemithi yokwelapha.

Ukupakisha nokuthumela

Ukupakisha:1kg/isikhwama se-foil;5kg/carton;25kg/fiber drum;noma ukupakisha njengesicelo sakho.

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Ekuphetheni

Ngamafuphi, njengomkhiqizi wempuphu ye-2-Deoxy-D-glucose ochwepheshe , sinobuchwepheshe obuthuthukisiwe, inzuzo yesikali, ikhwalithi engcono kakhulu, ulwazi lokukhiqiza olucebile, kanye nezinsizakalo ezinhle kakhulu. Lezi zinzuzo zizokwenza ivelele emncintiswaneni wemakethe futhi ithole ukwethenjwa okwengeziwe kwamakhasimende kanye nokusekelwa.

Uma ufuna ukwazi okwengeziwe nge- 2-DG noma unesifiso sokuyithenga, ungaxhumana nathi nganoma yisiphi isikhathi. Sizokuphendula ngokushesha okukhulu ngemva kokubona umlayezo.

imininingwane yethu yokuxhumana:

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