I-Azacytidine

Sihlinzeka nge-5- Azacytidine API

Siyaziqhenya ngokunikeza i -5- Azacytidine API , isakhi sokwelapha sekhwalithi ephezulu esisetshenziswa njenge-antineoplastic kanye ne-antiviral agent. Le API isetshenziswa kakhulu ekwelapheni i-acute myeloid leukemia, iphethini ye-myelodysplastic, kanye ne-habitual myelomonocytic leukemia. Umkhiqizo wethu wenziwe ngokuhambisana nezindinganiso zekhwalithi eziqinile, uqinisa ubumsulwa bawo kanye nokusebenza kwawo. Utholakala ngosayizi wokupakisha onemibala ukuze uvumelane nezimo zakho ezithile. Sithembe ukuthi sizokunikeza amandla athembekile futhi asebenzayo e-5- Azacytidine. Sitshele isikhathi ukuze ufunde kabanzi ngalo mkhiqizo nokuthi singakusiza kanjani.

Iyini i-Azacytidine?

5- Impuphu ye -Azacytidine , eyaziwa nangokuthi i-Azacitidine noma i-5-AC, iyikhemikhali. Iyi-analog ye-nucleoside eyenziwe ngesisekelo se-adenine kanye ne-patch efana nendandatho ekhethe i-heterocycle ye-nitrogen equkethe i-nitrogen. Iyimpahla ye-DNA methyltransferase futhi isetshenziswa njalo ukwelapha iphethini ye-myelodysplastic (MDS), isimo segazi. Igama layo lekhemikhali yi-4- Amino-1-(- D- ribofuranosyl)(1H)- eyodwa, kanti inombolo yayo ye-CAS ingu- 320-67-2 . Ifomula yayo yekhemikhali yi-C8H12N4O5, kanti isisindo sayo sama-molecule singama-244.2 g/ spook. Ingashintsha ukubonakaliswa kwezakhi zofuzo futhi ibe nezinzuzo zokulungisa ezimweni ezifana nephethini ye-myelodysplastic (MDS) ngokubheka inqubo ye-methylation ye-DNA. Ngokuvimbela izinguquko ze-methylation ye-DNA, ikhuthaza ukukhula kwamaseli e-hematopoietic anempilo futhi iguqula ukwakheka kwamaseli e-hematopoietic angaphelele.

Ukutholwa kokutholakala kwe-5-Azacytidine kubuyela emuva kuma-1950s. Uhlolojikelele lwemiphumela yalo lungatholakala lapha:

Ukuhlanganiswa kokuqala kwe -Azacytidine API kwenziwa ngo-1958 ngabahloli abavela kwi-Chemical Development Section ye-National Institutes of Health e-United States. Baqinisekisa ukuthi lesi sidakamizwa sivimbela i-methylation ye-DNA yeselula.

I-National Cancer Institute (NCI) e-United States yaqala ukuhlola okusha nge- azacytidine ngo-1964.

Impuphu ye-Azacitidine yadlula ekuhlolweni nasekuthuthukisweni okusha eminyakeni emashumi edlule. I-US Food and Drug Administration (FDA) yanikeza isibusiso se-Azacytidine (ephinde yathengiswa njenge-Vidaza) ngo-1985 ngokusebenza kwephethini ye-myelodysplastic eyingozi kakhulu (MDS). Ngenxa yalokho, ibilokhu isetshenziswa njalo ukwelapha i-MDS.

Ulwazi Basic

Igama lomkhiqizo: 5-Azacytidine
CAS:320-67-2
MF:C8H12N4O5
MW: 244.2
I-EINECS: 206-280-2
Inombolo ye-MDL:MFCD00006539
Ubumsulwa:99%
Ukuzinza: Izinzile iminyaka emi-2
ukunyibilika: I-Soluble ku-DMSO (kufika ku-25 mg/ml), noma Emanzini (kufika ku-12 mg/ml).
Isicelo: Ibanga lemithi noma elisetshenziselwa ucwaningo.
Ukupakisha: Njengesicelo sakho
Isitoreji: Izinga lokushisa legumbi.
Ifomula yesakhiwo:

Iphuzu elincibilikayo: 226 kuya ku-232 ℃

Indawo yokubilisa: 534.5 ℃

Ukuncibilika kwamanzi: ukuncibilika

Ukuminyana: 2.08 g/cm ³

Iphoyinti elikhanyayo: 277 ℃

Quality ejwayelekile

Ukupakisha: 500g/isikhwama;1kg/isikhwama

Izimo zokugcina: -20 ℃, umswakama-ubufakazi, ukuvalwa, nokukhanya okulula

Izimo zokuhamba: 2-8 ℃ ezokuthutha

Isigaba: Izinto ezinobuthi

Ukuhlukaniswa kobuthi: kunobuthi kakhulu

Ubuthi obunamandla: I-Oral LD50 kumagundane: 572 mg/kg; Igundane lomgodi wesisu LD50: 68 mg/kg

Izici eziyingozi ezivuthayo: ezivuthayo; Ukushiswa kukhiqiza intuthu ye-nitrogen oxide enobuthi; Imiphumela emibi yemithi ezigulini: isicanucanu, ukuhlanza, isifo sohudo, nokuncipha kwamangqamuzana egazi amhlophe

I-ejenti yokucisha: impushana eyomile, igwebu, isihlabathi, isikhutha, amanzi ane-athomu

Iyini isicelo ye-5-Azacytidine powder ?

Lokhu okulandelayo ukusetshenziswa okuyinhloko kwe -5-Azacytidine powder kanye nezindawo zokusetshenziswa kwayo:

1.Izidakamizwa ezilwa namagciwane

Inkomba eyinhloko i-acute myeloid leukemia engasebenzi ngokumelene nokwelashwa okuvamile. Ibuye isetshenziselwe umdlavuza webele, melanoma, umdlavuza wamathumbu, njll Ukubonakaliswa okuyinhloko kobuthi yi-leukopenia, i-thrombocytopenia, ne-anemia. Isicanucanu nokuhlanza kuyizimo ezimbi ezivamile, ezingathuthukiswa ngokumuselwa isikhathi eside noma ngokusebenzisa imishanguzo ye-antiemetics emahoreni angama-24 kuya kwangu-48 ngaphambi kokwelashwa. Eminye imiphumela enobuthi ihlanganisa isifo sohudo, ukuphazamiseka kwe-neuromuscular, umkhuhlane, i-hypotension, nokuqubuka. Ukwakheka kusanda kulungiswa amahora angama-3-4 ngaphambi kokusetshenziswa.

I-2.I-inhibitor enamandla yokukhula kanye ne-cytotoxic agent

Ukuvinjelwa kwe-DNChemicalbookA methyltransferase, indlela ebalulekile yokulawula yokuvezwa kofuzo, ukwenziwa kusebenze, kanye nokuthulisa; Izicindezelo zomdlavuza ezinomsebenzi obuthakathaka we-antibody (i-Gram positive); Isetshenziselwa ukutadisha umphumela we-DNA yokuhlanganisa ama-molecule ngesikhathi senqubo ye-DNA methylation

3. Isici esivimbela ukukhula esingaba khona nesithwali se-cytotoxic

Ukuvimbela i-DNA methyltransferase, okuyindlela ebalulekile yokulawula yokuvezwa kwezakhi zofuzo, ukusebenza kwezakhi zofuzo, nokuvalwa kwezakhi zofuzo. Lesi sici sibangela i-DNA demethylation noma i-semi demethylation, okuvumela izici zokuloba ukuthi zibophe ku-DNA futhi zivuselele izakhi zofuzo zokucindezela isimila.

Ulwazi lwezokuphepha

Ilebula lezimpahla eziyingozi: T

Ikhodi yesigaba sezingozi: 45-46-22

Safety instructions: 53-22-36/37/39-45

I-WGK Germany: 3

Inombolo ye-RTECS: XZ3017500

F: 10-23

Ikhodi yamasiko: 29349990

Idatha Yezinto Ezinobuthi: 320-67-2

Ubuthi: LD50 kumagundane (mg/kg): 115.9 ip; 572.3 Ngomlomo (Palm, Kensler)

Isenzo sempilo

I-Azacytidine inethonya layo lokulwa nomdlavuza ngokunciphisa i-DNA methylation kanye nokusebenzisa ubuthi obuqondile kumaseli e-hematopoietic angajwayelekile e-bone marrow. Izifundo ze-in vitro zikhombisile ukuthi ukuhlushwa kwalomkhiqizo ekuvinjelweni okuphezulu kwe-DNA methylation akukuvimbeli kakhulu ukwakheka kwe-DNA. Isenzakalo se-methylation ephansi singabuyisela ukusebenza okujwayelekile kwezakhi zofuzo ezihlobene kakhulu nokwehlukaniswa nokwanda kwezincwadi zamakhemikhali ezinhle. Umphumela we-cytotoxic walo mkhiqizo ungabangela ukufa kwamaseli akhula ngokushesha, kufaka phakathi amaseli omdlavuza alahlekelwe ukulawulwa okuvamile kokusebenza, kuyilapho amaseli angakhuli engazweli kangako kulo mkhiqizo. Ukubuka konke, izakhiwo ze-physicochemical, izindlela zokulungiselela, imiphumela yezokwelapha, kanye nokusetshenziswa kwe-azacitidine

Zethu Advantage

Okuhlangenwe nakho okucebile: Sineminyaka engu-13 yesipiliyoni sobuchwepheshe;

Amakhasimende emhlabeni wonke: adayisela emazweni angaphezu kwekhulu;

Hlinzeka ngemikhiqizo ehlukahlukene: imikhiqizo isetshenziswe kuzo zonke izinhlobo ezinkulu zamazwe ngamazwe emkhakheni wezidakamizwa, izithasiselo zokudla, izimonyo, umsoco wezilwane kanye nokudla okusebenzayo.

Intengo kusengaphambili: i-MOQ ephansi ngentengo yokuncintisana;

Isitifiketi sekhwalithi: ISO; I-Halal; I-Kosher iqinisekisiwe

Isevisi yangemuva kokuthengisa: Ithimba lochwepheshe amahora angu-7*24 isevisi yamakhasimende.

Ngamafuphi, njengomkhiqizi we -Azacitidine API ochwepheshe , sinobuchwepheshe obuthuthukisiwe, inzuzo enkulu, ikhwalithi engcono kakhulu, ulwazi lokukhiqiza olucebile, kanye nezinsizakalo ezinhle kakhulu. Lezi zinzuzo zizokwenza ivelele emncintiswaneni wemakethe futhi ithole ukwethenjwa nokusekelwa okwengeziwe kwamakhasimende.

imininingwane yethu yokuxhumana: 

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